This is a worldwide bibliography of the Grand Canyon and lower Colorado River regions in southwestern United States and northwestern Mexico (in Arizona, Nevada, California, Baja California and Sonora). It divides into 32 subject areas 90,000 citations in 95 languages published during 484 years—from circa 1535 to 2018—produced in countries from Afghanistan to Zimbabwe. Proving a long-lasting, worldwide engagement with this region, the items embrace general and specific subjects including history, biography, and geography; social, natural, physical, and environmental sciences; engineering projects and water management policies; administrative oversight; legislative and judicial affairs; concerns of public-interest and special-advocacy organizations; interests and activities of Indigenous peoples; and works for and by youth and young adults. Publications are commonplace, technical, and specialized; in inkprint, special media for the visually impaired, and audio, audio-visual and digital media. They have been published in popular, academic, commercial and governmental venues, and privately.